About The Preeclampsia Registry

Study | Aim(s)

Publication or Presentation

Lead Investigator

The patient journey during and after a preeclampsia-complicated pregnancy: a cross-sectional patient registry study

Aim 1: Ascertain and describe the Patient Journey in the setting of PE from the patient’s point of view.

Aim 2: Understand the interactions between patients and care providers and the decision-making process.

BMJ Open (2022)

Thesis (2024)

R.C. Rianne Bijl. MD

M.P.H. Wendy Koster, MD, PhD

Erasmus University

Information needs and experiences from pregnancies complicated by hypertensive disorders: a qualitative analysis of narrative responses

Aim 1: To identify and examine the information needs of women with hypertensive disorders of pregnancy

BMC Pregnancy & Childbirth (2021)

Swati Shree, MD

University of Washington

Women’s attitudes, beliefs and values about tests, and management for hypertensive disorders of pregnancy

Aim 1: Understand the patient perspective of PE tests and treatments.

BMC Pregnancy & Childbirth (2021)

Shenaz Ahmed, PhD

University of Leeds

Cardiomyopathy and Preeclampsia: Shared Genetics?

Aim 1: Determine whether cardiomyopathy gene mutations are also a contributory factor in preeclampsia

Circulation (2018)

Hilary Gammill, MD

University of Washington

HMOX1 Genetic Polymorphisms Display Ancestral Diversity and May be Linked to Hypertensive Disorders in Pregnancy

Reproductive Sciences for Springer (2022)

Tianyanxin Sun, PhD

Stanford University

Patient-Reported Pre-conceptional Characteristics in the Prediction of Recurrent Preeclampsia

Aim 1: Determine if periconceptional cardiovascular risk factors in women are correlated with risk of recurrence of PE.

Aim 2: Compare cardiovascular adaptation in women with and without a history of PE.

Pregnancy Hypertension: An International Journal of Women’s Cardiovascular Health (2022)

M.P.H Wendy Koster, MD, PhD

R.C. Rianne Bijl. MD

Erasmus University

Cell-type specific differences between preeclampsia and normal placentas using unbiased single-cell RNA-sequencing

Aim 1: Gene expression of the placenta across the PE spectrum, at single-cell resolution

Aim 2: An open web resource of the molecular human placenta in health and disease

Elsevier (2023)

Amit Zeisel, PhD Assistant Professor,

Ido Solt, MD Clinical Assistant Professor

Sisterhood Study: Recruiting and retaining nulliparous individuals with a family history of hypertensive disorders of pregnancy to participate in scientific research prior to pregnancy

Aim 1: Evaluate the feasibility of conducting a large preconception cohort study to prospectively evaluate the impact of PE on CV health.

Aim 2: Collect preconception BP data as a measure of engagement

Science Direct (2023)

Sadiya Khan, MD MS

Northwestern University

Impact of tissue porosity and asymmetry on the oxygen uptake of the human placenta: A numerical study

-Placenta (2022)

Romina Plitman Mayo

Early Assessment of Pregnancy Complications: Placental Characterization based on Ultrasound Images and Numerical Biomechanical Models

Aim 1: To correlate placental transport capacity from in-silico models with in-vivo data

Aim 2: To correlate placental density with in-vivo ultrasound echotexture

Aim 3: To estimate the risk of developing PE using routine 2nd trimester scans

Presented findings, May 2023 to Global Pregnancy CoLab (webinar)

Published manuscript in Placenta 2022

Dr. Romina Plitman-Mayo,

Department of Immunology and Regenerative Biology, Weizmann Institute of Science

High-Throughput Methylome Analysis of Early and Late Onset Preeclampsia

Aim 1: Quantify and compare DNA methylation signatures associated with early and late onset PE in mothers and infant pairs. 

-Physiological Genomics (2024)

Kent Thornburg, PhD

Oregon Health Sciences University