MTHFR Gene Not Associated With Bipolar Disorder.
MedWire (6/25, Piper) reports that, according to a study published online in the American Journal of Medical Genetics Part B: Neuropsychiatric Genetics, "a variant of the 5,10-Methylenetetrahydrofolate reductase (MTHFR) gene...is not associated with clinically significant bipolar disorder." In a "study of the MTHFR C677T polymorphism in 897 patients with bipolar I or bipolar II disorder and 1687 mentally healthy control individuals," researchers "found no significant difference in the genotype and allele frequencies of the C677T polymorphism between the patients with bipolar disorder and the controls, with 45.6% of patients in each group carriers of the CT genotype." A meta-analysis of eight articles on the subject also found "no increased risk for bipolar disorder" among those carrying the 677T allele or the 677TT genotype.
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