Associations between phenotypes of preeclampsia and thrombophilia

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caryn
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Associations between phenotypes of preeclampsia and thrombophilia

Postby caryn » Fri Nov 06, 2015 05:52 pm

"Early onset preeclampsia, especially if complicated by fetal growth restriction, are associated with anti-phospholipid antibodies. Other phenotypes of preeclampsia, especially HELLP syndrome, were not associated with thrombophilia. We advise only to test for anti-phospholipid antibodies after early onset preeclampsia, especially if complicated by fetal growth restriction. We suggest enough evidence is presented to justify no further studies are needed."

http://www.ncbi.nlm.nih.gov/pubmed/26444331

So this study tested every preeclamptic/HELLP patient who was willing to be tested who came through the facility between 1985, and 2010. That's a quarter-century of cases - and the only statistically relevant association was between early onset preeclampsia, and APAs. Lots of people had thrombophilias, but not more than we see in the regular population, and not in a way that was associated with these pregnancy complications.
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