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Re: The complement system and adverse pregnancy outcomes

Posted: Sat Jan 03, 640533 2:18 pm
by caryn

Re: The complement system and adverse pregnancy outcomes

Posted: Wed Aug 30, 640530 11:27 pm
by caryn
...and at the moment, I'm locked from posting links as a potentially spammy "new user", with my +10,000 posts since 2006. LOL. Well, if you copy-paste the quoted text into Google, it will take you to the PubMed abstract.

The complement system and adverse pregnancy outcomes

Posted: Wed Aug 30, 640530 9:23 pm
by caryn
"The innate and adaptive immune system must be regulated to insure survival of the fetal allograft, and the complement system is no exception. An intact complement system optimizes placental development and function and is essential to maintain host defense and fetal survival. Complement regulation is apparent at the placental interface from early pregnancy with some degree of complement activation occurring normally throughout gestation. However, a number of pregnancy complications including early pregnancy loss, fetal growth restriction, hypertensive disorders of pregnancy and preterm birth are associated with excessive or misdirected complement activation..."



So this is something of a review; we've known for over a decade that the immune response to the foreign placenta is very, very deeply involved with any of the conditions under the preeclampsia umbrella. The complement cascade is part of a runaway response that the immune system mounts to foreign proteins like those the placenta presents to our systems. Pregnancy is all about tolerating and working with that foreign organ, and in preeclampsia/ HELLP/ IUGR something goes wrong...

Wikipedia has a lot on the complement cascade, if you really feel like a lot of hard reading. I'll try to write up something easier shortly!