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Vasopressin: The Missing Link for Preeclampsia?

Posted: Fri Apr 03, 2015 01:11 am
by caryn
"Various lines of evidence support a "tissue rejection" type reaction toward the placenta as the primary initiating event in the development of preeclampsia, followed by a complex interplay among immune, vascular, renal, and angiogenic mechanisms that have been implicated in the pathogenesis of preeclampsia beginning around the end of the first trimester. Critically, it remains unclear what mechanism links the initiating event and these pathogenic mechanisms."

http://www.ncbi.nlm.nih.gov/pubmed/25810383

So, in mice, injecting arginine vasopressin creates preeclampsia symptoms - which might mean it's one of the triggers of preeclampsia symptoms in humans. If we could block the activity of triggers of the symptoms, at least some pregnancies could be sustained for longer. Blocking these triggers wouldn't implant the placenta better, so there are cases that wouldn't be helped by this, but anything that allows docs to block or delay the onset of symptoms would likely allow many preeclamptic pregnancies to last longer. I'll take "days not in NICU" and "time for steroids", so I hope this is supported in followup research!