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impact of donor insemination on the risk of preeclampsia

Posted: Wed Nov 05, 2014 09:09 am
by caryn
"Altogether, 10,898 women (2342 pregnancies by donor sperm versus 8556 by the partner's sperm) were included from seven observational studies. Conception using donor sperm was associated with an increased risk of preeclampsia (odds ratio [OR] 1.63, 95% CI 1.36-1.95) compared with using a partner's sperm."

http://www.ncbi.nlm.nih.gov/pubmed/25282539

Well, that's more support for the "dysregulated immune response" hypothesis. Your immune system wouldn't have any way to recognize donor sperm, but probably recognizes the sperm from a regular partner. That's called "seminal priming" - here's a paper from a decade ago where this idea was being examined in more mechanical detail: http://www.jrijournal.org/article/S0165 ... 4/abstract