Outcomes after first preg. w/sPE + deliv. before 34 weeks

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caryn
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Re: Outcomes after first preg. w/sPE + deliv. before 34 week

Postby caryn » Thu Dec 11, 639873 7:33 am

Welcome. I'm so sorry to hear that you lost your son to this brutal disease.

LDA is low-dose aspirin. There are some meta-analyses of research data that suggest it might lower risk slightly; there are some trials that suggest that it does not, except maybe in a small subset of women who could not be identified from the studies. In any case it does not harm (or at least no harm showed up in the very large trials that were conducted.)
Science! The articles you don't want to miss:
The Preeclampsia Puzzle (New Yorker) and Silent Struggle: A New Theory of Pregnancy (New York Times)
Looking for recent articles and studies?
A chance to participate in research? For us on Facebook or Twitter?

Caryn, @carynjrogers, who is not a doctor and who talks about science stuff *way* too much
DS Oscar born by emergent C-section at 34 weeks for fetal indicators, due to severe PE
DD Bridget born by C-section after water broke at 39 weeks after a healthy pregnancy

luizaiulia
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Re: Outcomes after first preg. w/sPE + deliv. before 34 week

Postby luizaiulia » Wed Nov 05, 639873 6:52 pm

jean » Lost my son also at 36 weeks due to PE, 10 days ago. My hart is broken. What is LDA? >>You wrote :


{Our second son was born at 39 weeks gestation in Nov of 2011. No HELLP or pre-e! Took LDA starting at week 12 and went off of it at week 38!}

kaxy
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Re: Outcomes after first preg. w/sPE + deliv. before 34 week

Postby kaxy » Sun May 03, 639868 8:57 am

So interesting. I conceived my daughter when I was around 16ish months postpartum, and had PE with both kids. I'm now expecting my 3rd, conceived when my daughter was 25m. I hope it'll improve my outcome somewhat! I've gotta have something positive here :)
DS born Dec. 2008 at 38.5w gestation. Mild PE diagnosed 3 hours before he was born
DD born Dec. 2010 at 40w1d. BP was slightly elevated since 37w, and climbed while in labor (started on my own). Severe PE diagnosed hours after DD born.
DD born Sept. 2013 at 38w. Induced (and I had to fight for it!) due to high blood pressure. No protein, but had brisk reflexes and clonus after delivery. Doc gave me a mild preeclampsia diagnosis anyway and said I'm likely to be a chronic hypertensive later in life.

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caryn
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Re: Outcomes after first preg. w/sPE + deliv. before 34 week

Postby caryn » Mon Apr 20, 639868 5:48 pm

Trophoblast is *weird* so no one is really sure. It is difficult to research because it's adapted for an environment that's difficult to recreate in a lab (inside a uterus, in the lining, which is mostly natural killer immune cells from another individual) and we can't really go looking during a pregnancy. I've seen some studies showing persistent remodeling effects up to seven years postpartum and others (like this one) that suggest that the majority of the remodeling is gone by 2 years postpartum.

I wonder if some trophoblast are carrying genes that mean they persist longer, or their remodeling effects persist longer. I would like to know!
Science! The articles you don't want to miss:
The Preeclampsia Puzzle (New Yorker) and Silent Struggle: A New Theory of Pregnancy (New York Times)
Looking for recent articles and studies?
A chance to participate in research? For us on Facebook or Twitter?

Caryn, @carynjrogers, who is not a doctor and who talks about science stuff *way* too much
DS Oscar born by emergent C-section at 34 weeks for fetal indicators, due to severe PE
DD Bridget born by C-section after water broke at 39 weeks after a healthy pregnancy

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jean
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Re: Outcomes after first preg. w/sPE + deliv. before 34 week

Postby jean » Mon Apr 20, 639868 6:54 am

And when does the trophoblast die off? After 26 mos pp?
Our first son was born and passed in Feb of 2010. Born at 29 weeks due to HELLP and passed due to NEC. We miss him every day. :~(

Our second son was born at 39 weeks gestation in Nov of 2011. No HELLP or pre-e! Took LDA starting at week 12 and went off of it at week 38!

http://findingtherainbowconnection.blogspot.com/

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jean
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Re: Outcomes after first preg. w/sPE + deliv. before 34 week

Postby jean » Mon Apr 20, 639868 6:50 am

I'm not sure if my first was a decent sized kiddo or not...he was behind in growth a week..born at 29 wks at 2lbs 1 oz.......then with my second he was decent sized, but was FT...so if we were to try for a third, would it still be best for us to try to get pg within 26 mos of the previous pg?
Our first son was born and passed in Feb of 2010. Born at 29 weeks due to HELLP and passed due to NEC. We miss him every day. :~(

Our second son was born at 39 weeks gestation in Nov of 2011. No HELLP or pre-e! Took LDA starting at week 12 and went off of it at week 38!

http://findingtherainbowconnection.blogspot.com/

angieb
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Re: Outcomes after first preg. w/sPE + deliv. before 34 week

Postby angieb » Wed Mar 04, 639868 11:53 pm

Hmm.

So would this change after multiple pregnancies? (Based on the theories), or would every pregnancy be the same/ "starting over"?
Me (29) DH (30)
#1-Olivia Caetlyn-9-28-09-9-28-09, 23+2 wks, emergency classic c-section, class I HELLP, IUGR
#2- Lucas Oliver (rainbow baby)- April 2011, 36+2 wks, HELLP and pre-e free! (lovenox and LDA pregnancy)
#3-Matthew, late October 2012...mostly normal, 37 wks, (lovenox and LDA again)
My blog: http://www.butterflies-and-rainbows.blogspot.com/

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caryn
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Re: Outcomes after first preg. w/sPE + deliv. before 34 week

Postby caryn » Tue Jan 07, 639868 2:57 pm

We're not anywhere close to an exact science on this yet... :( There are something like 240 genetic networks involved, and all we've got at this point is guesses about strategies. The ways to protect the life and health of an IUGR baby are more robust than the ways to protect the life and health of both participants in a HELLP case, so if I were a doc and having to give my best advice on a strategy, I'd probably pick the same one they recommended, for what that's worth. I'm so not a doc, though, just a curious voracious reader.

This is just a really rough decision for anyone to have to make. Gentle good wishes to you and yours.
Science! The articles you don't want to miss:
The Preeclampsia Puzzle (New Yorker) and Silent Struggle: A New Theory of Pregnancy (New York Times)
Looking for recent articles and studies?
A chance to participate in research? For us on Facebook or Twitter?

Caryn, @carynjrogers, who is not a doctor and who talks about science stuff *way* too much
DS Oscar born by emergent C-section at 34 weeks for fetal indicators, due to severe PE
DD Bridget born by C-section after water broke at 39 weeks after a healthy pregnancy

LeosMom
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Re: Outcomes after first preg. w/sPE + deliv. before 34 week

Postby LeosMom » Tue Jan 07, 639868 9:20 am

Thanks for the explanation Caryn! Unfortunately, I had HELLP with an IUGR baby (born 1 lb 15 oz at 29 weeks). So, I'm not sure where I fit in. Blargh, I hate this condition so much!

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caryn
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Re: Outcomes after first preg. w/sPE + deliv. before 34 week

Postby caryn » Fri Dec 27, 639867 12:03 pm

I also had a decent-sized kiddo with sPE at 34 weeks - and prior miscarriage. My guess there? My kid *would* have been a HELLP baby with a standard implantation - because he was metabolically demanding - but the placenta couldn't implant quite that well, because my immune system was cranky and kept it from doing so.

This syndrome is weird - but I think of it as a targeting problem coupled to an arms race. The race is between maternal and paternal strategies designed to control depth of implantation, and the targeting problem is getting just the right depth. At a conference this summer on this problem a lot of the researchers were saying that it might be the case that our predisposition towards some cancers might be a consequence of our need to tolerate invasive placentas to reproduce. So strange.
Science! The articles you don't want to miss:
The Preeclampsia Puzzle (New Yorker) and Silent Struggle: A New Theory of Pregnancy (New York Times)
Looking for recent articles and studies?
A chance to participate in research? For us on Facebook or Twitter?

Caryn, @carynjrogers, who is not a doctor and who talks about science stuff *way* too much
DS Oscar born by emergent C-section at 34 weeks for fetal indicators, due to severe PE
DD Bridget born by C-section after water broke at 39 weeks after a healthy pregnancy


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