...Progesterone abolished TNF-alpha-stimulated ET-1 from endothelial cells. TNF-alpha-induced hypertension was associated with significant increases in renal and placental ET-1. Administration of 17-OHP attenuated TNF-alpha-induced hypertension and decreased renal ET-1...
Well, *that's* interesting. The previous investigations into progesterone dosing in humans with gestational hypertension didn't result in a theraputic effect, IIRC, but apparently this particular version of progesterone blocks one particular part of the cascade in gestational hypertension (not the soluble Flt portion, but the TNF-alpha portion) and might be useful as a therapy, though they'll have to run a trial so see if it works in people as opposed to rats. And even if it blocks that part of the cascade, it might not have any effect on the progression of the disease (which would explain nicely why progesterone hasn't seemed to have a theraputic effect wrt the progression of preeclampsia per se.)
Information provided on this site is provided for informational purposes only and is not meant to substitute for the advice provided by your own physician or other medical professional. You should not use the information contained herein for diagnosing or treating a health problem or disorder, or prescribing any medication. The Preeclampsia Foundation presents all data as is, without any warranty of any kind, express or implied, and is not liable for its accuracy, for mistakes or omissions of any kind, nor for any loss or damage caused by a user's reliance on information obtained on the site. Professional opinions on this condition vary greatly. The Preeclampsia Foundation endorses no one course of treatment or "cure".
The Preeclampsia Foundation does not necessarily endorse any research or news found in this forum, we just want to share what is out there. Please use your own discretion to evaluate any information you find here.
1 post • Page 1 of 1
Users browsing this forum: No registered users and 5 guests