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Immunoactivation in PE: Vdelta2+ and Treg

Posted: Wed Apr 29, 2009 02:35 pm
by caryn
Recent data suggest a dominant role of the innate, rather than the adaptive immune system in pregnancy-related immunoregulation. gamma/delta T cells, that comprise a minor subpopulation of human peripheral blood lymphocytes, represent a link between the innate and the acquired immune systems. However little is known about how they function in preeclampsia, which is suggested to be associated with a Th1 predominant immune response... Our data suggest that activated Vdelta2+ T cells of preeclamptic women have an increased cytotoxic potential, which may be due to altered expression of NK cell inhibitory and activating receptors. In this study we report a series of observations, which taken together suggest the role of multiple pathways in generating an exaggerated systemic inflammatory response observed in the clinical stage of preeclampsia.

So I was just babbling about this in another post. :-)

They used to think the inflammation was all innate immunity. Then they got this data saying oh, there's some components of adaptive immunity (and that didn't make much theoretical sense.) It seems to be coming down to "dysregulation" of the NK cells in the uterus, which are modulated by signals sent from the trophoblast as I understand it. And it's multiple pathways, which means we break in a *bunch* of different ways, which is one reason this disease is so hard to think about and manage.

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