novel trophoblast-enriched sFlt1 variant is upregu

The Preeclampsia Foundation does not necessarily endorse any research or news found in this forum, we just want to share what is out there. Please use your own discretion to evaluate any information you find here.
User avatar
Forum Moderator
Posts: 10203
Joined: Fri Jun 25, 2004 06:36 am

novel trophoblast-enriched sFlt1 variant is upregu

Postby caryn » Mon Apr 06, 2009 04:00 am

...sFlt1-e15a emerged as an alternate transcript of Flt1 late in evolution with the insertion of an AluSq sequence into the primate genome after the emergence of the simian infraorder about 40 mya ago. sFlt1-e15a is particularly abundant in human placenta and trophoblasts and is also highly expressed in non-human primate placenta... Consistent with a role in placental pathophysiology, hypoxia stimulates sFlt1-e15a expression in isolated cytotrophoblasts and in a trophoblast cell line and differentiation into syncytiotrophoblasts further enhances the effect of hypoxia. Placental levels of sFlt1-e15a and sFlt1-i13 transcripts are significantly elevated in patients with preeclampsia compared to normal pregnancies...

So that would explain why we're the only ones who get it; we've got more of this particular gene variant expressed in our placentas than other primates. (That means we've all got it, but it gets turned on more often in ours...)

Information provided on this site is provided for informational purposes only and is not meant to substitute for the advice provided by your own physician or other medical professional. You should not use the information contained herein for diagnosing or treating a health problem or disorder, or prescribing any medication. The Preeclampsia Foundation presents all data as is, without any warranty of any kind, express or implied, and is not liable for its accuracy, for mistakes or omissions of any kind, nor for any loss or damage caused by a user's reliance on information obtained on the site. Professional opinions on this condition vary greatly. The Preeclampsia Foundation endorses no one course of treatment or "cure".

Return to “Announcements and Preeclampsia in the News”

Who is online

Users browsing this forum: No registered users and 2 guests