Proteomic profiling of urine identifies PE biomark

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caryn
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Re : Proteomic profiling of urine identifies PE biomark

Postby caryn » Mon Feb 02, 2009 04:35 pm

That's exactly why they're looking at it (and a lot of other things), but any early detection test hasn't been formalized yet.

jenh
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Re : Proteomic profiling of urine identifies PE biomark

Postby jenh » Mon Feb 02, 2009 03:13 pm

Are misfolded proteins something my local lab can test for, or is that still off in the future? It would be so nice to have that much early warning.

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Re : Proteomic profiling of urine identifies PE biomark

Postby jamie w » Mon Feb 02, 2009 11:58 am

WOW!!! I am sooo excited to hear this!!!!

ozierja
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Re : Proteomic profiling of urine identifies PE biomark

Postby ozierja » Mon Feb 02, 2009 08:42 am

Everyone is talking about it:
Research suggests preeclampsia may stem from misfolded proteins.
HealthDay (1/30, Preidt) reported that "misfolded proteins may be the cause of preeclampsia, say Yale University researchers" who studied 111 pregnant women. The team "identified key abnormal proteins in the women's urine weeks before they showed clinical signs of preeclampsia." Notably, the "urine test" that was developed "was based on a dye that sticks to misfolded, or incorrectly formed, proteins." During their presentation on Jan. 30 before the Society for Maternal-Fetal Medicine's annual meeting, the authors pointed out that, in the near future, they "will seek to determine whether the different shapes employed by the misfolded proteins in preeclampsia are linked to specific clinical symptoms and the different ways this intriguing disease manifests."

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Re : Proteomic profiling of urine identifies PE biomark

Postby jenchar » Sun Feb 01, 2009 01:52 am

They mention SERPINA - A1...this is the protein for Alpha-1 antitrypsin.

I'm a gene carrier for this deficiency, and both of my children have the ZZ severe form of the deficiency.

I'm excited about this research and how Alpha-1 Antitrypsin affects the development of preeclampsia. As a two-time severe PE survivor, this research means the world to me.

Can ya tell I'm excited?

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caryn
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Re : Proteomic profiling of urine identifies PE biomark

Postby caryn » Sat Jan 31, 2009 09:09 pm

"Our findings are compelling for several reasons," she said. "This novel identification of preeclampsia as a disorder of protein misfolding opens a door for researchers that may lead to testing of new drugs or developing new therapies. Our future work will seek to determine whether the different shapes employed by the misfolded proteins in preeclampsia are linked to specific clinical symptoms and the different ways this intriguing disease manifests."

http://tinyurl.com/bxhkaa

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caryn
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Proteomic profiling of urine identifies PE biomark

Postby caryn » Mon Nov 10, 2008 02:09 pm

In preeclampsia, increased and aberrant SERPINA1 immunoreactivity was found in urine, serum, and placenta, in which it localized predominantly to placental villi and placental vascular spaces adherent to the endothelium. In addition, significant perivascular deposits of misfolded SERPINA1 aggregates were exclusively identified in preeclamptic placentae. CONCLUSION: Proteomics-based characterization of urine in preeclampsia identified a proteomic fingerprint composed of SERPINA1 and albumin fragments, which can accurately diagnose preeclampsia and shows promise to discriminate it from other hypertensive proteinuric diseases. These findings provide insight into a novel pathophysiological mechanism of preeclampsia related to SERPINA1 misfolding, which may offer new therapeutic opportunities in the future...

http://www.ncbi.nlm.nih.gov/pubmed/18984079

So this is *really* interesting. They could spot preeclamptics +10 weeks before symptoms appeared because they had a misfolded protein appearing in their urine. When proteins "fold" wrong, they don't fit the biochemical lock any more, and whatever it is that they ordinarily do in the body pretty much doesn't happen.

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