Increased Myeloperoxidase in Placenta, Circulation

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Increased Myeloperoxidase in Placenta, Circulation

Postby caryn » Sun Jul 06, 2008 05:20 am

Myeloperoxidase (MPO) is a hemoprotein normally released from activated monocytes and neutrophils. Traditionally viewed as a microbicidal enzyme, MPO also induces low-density lipoprotein oxidation, activates metalloproteinases, and oxidatively consumes endothelium-derived NO... MPO levels in placental extracts from women with preeclampsia were significantly higher than the levels in normal control subjects (546+/-62 versus 347+/-32 ng/mL; P=0.025)...Plasma MPO levels were 3-fold higher in patients with preeclampsia compared with normal control subjects (36.6+/-7.6 versus 11.0+/-3.1 ng/mL; P=0.003). In conclusion, MPO levels are significantly increased in the circulation and placenta of women with preeclampsia.

(So it's not that you're not eating enough antioxidants; it's that your white blood cells are producing a whole lot of a chemical that acts like an oxidant, because it's a microbicide, and the placenta is foreign...)

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