PE associated with dendritic cell recruitment!

The Preeclampsia Foundation does not necessarily endorse any research or news found in this forum, we just want to share what is out there. Please use your own discretion to evaluate any information you find here.
User avatar
caryn
Forum Moderator
Posts: 10203
Joined: Fri Jun 25, 2004 06:36 am

Re : PE associated with dendritic cell recruitment!

Postby caryn » Thu Dec 20, 2007 01:49 pm

Yeah, the idea is that the widening of the spiral arteries takes place because the fetal portion of the placenta is "remodelling" the maternal portion -- and if the maternal immune system is fighting off those cells and keeping them from doing the remodelling job, then it doesn't happen. So months later, the placenta can't get enough blood and starts to dump sFlt-1, which causes many of the symptoms of PE.

This theory is still being hotly debated, but we're getting more and more empirical confirmation for it every time new studies come out. It may be only part of the truth, but it's way more than we had, you know?

ETA: This, of course, is an attempt to explain what they're thinking about the "true" preeclampsia cases -- and not the chronic hypertensives etc. who develop it in every pregnancy. There the idea is that they can't handle that much *more* inflammation on top of their existing baseline inflammatory levels.

dja
Registered User
Posts: 895
Joined: Fri Apr 09, 2004 11:22 am

Re : PE associated with dendritic cell recruitment!

Postby dja » Thu Dec 20, 2007 03:17 am

Okay - I think I get it, but does this confirm the basic idea that with PE, you end up having a placenta that doesn't have the correct spiral arteries (is that he trophoblast part?)??? I seem to recall reading somewhere that the PE-ridden placenta had inadequate spiral arteries or something.

taras mom
Registered User
Posts: 841
Joined: Thu May 01, 2003 01:30 am

Re : PE associated with dendritic cell recruitment!

Postby taras mom » Tue Dec 18, 2007 01:53 am

quote:Originally posted by Caryn

. . . the maternal portion of the placenta, the decidua, is chock-full of pissed off dendritic cells

Must you get so technical?[;)]

This IS fascinating.

sandy
Registered User
Posts: 1138
Joined: Thu Sep 25, 2003 09:58 am

Re : PE associated with dendritic cell recruitment!

Postby sandy » Mon Dec 17, 2007 03:56 pm

Thank you for the layman interpretation, Caryn.

Fascinating!!

User avatar
caryn
Forum Moderator
Posts: 10203
Joined: Fri Jun 25, 2004 06:36 am

PE associated with dendritic cell recruitment!

Postby caryn » Mon Dec 17, 2007 03:19 am

...Interleukin-1beta (IL-1beta), a pro-inflammatory cytokine, has been implicated in the genesis of pre-eclampsia. Thus, we postulate that pre-eclampsia would be associated with enhanced decidual dendritic cells infiltration and that IL-1beta would enhance the production of relevant dendritic cell-recruiting chemokines. We used immunohistochemistry to demonstrate a marked infiltrate of immature and mature dendritic cells in pre-eclamptic decidua. Further, immunohistochemistry and immunoassays of placental bed biopsies revealed that pre-eclamptic decidua displays elevated levels of several monocyte- and dendritic cell-recruiting chemokines. Leukocyte-free first-trimester decidual cells were then treated with IL-1beta, which enhanced the mRNA and protein expression of these chemokines. The current study also confirmed previous reports that macrophages directly impaired trophoblast invasion and that this inhibitory effect is augmented by the conditioned medium of IL-1beta-treated first-trimester decidual cells. However, unlike macrophages, dendritic cells did not directly impede trophoblast invasion. This study demonstrates that the inflammatory milieu of pre-eclampsia induces decidual cells to promote dendritic cell infiltration...

http://tinyurl.com/26n5zn

This is just fascinating, a beautiful example of how this whole "hey, maybe it's your immune system!" research stream is panning out in further work. Because they noticed changes in cytokine levels in preeclamptics, they were able to make a prediction about what they'd find, go looking for it, and find it. Very nice science. [:p]

Simply put in English, this is a confirmation that the maternal portion of the placenta, the decidua, is chock-full of pissed off dendritic cells -- which are the ones that recognize foreign invaders (foreign proteins, foreign antigens) and help rally the troops, the macrophages and other immune-system cells that do the actual job of fighting off the foreign invaders.

And that's just the *abstract*. I gotta pull the full-text.

Information provided on this site is provided for informational purposes only and is not meant to substitute for the advice provided by your own physician or other medical professional. You should not use the information contained herein for diagnosing or treating a health problem or disorder, or prescribing any medication. The Preeclampsia Foundation presents all data as is, without any warranty of any kind, express or implied, and is not liable for its accuracy, for mistakes or omissions of any kind, nor for any loss or damage caused by a user's reliance on information obtained on the site. Professional opinions on this condition vary greatly. The Preeclampsia Foundation endorses no one course of treatment or "cure".


Return to “Announcements and Preeclampsia in the News”

Who is online

Users browsing this forum: No registered users and 2 guests