protein imbalance can predict pregnancy disorder

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caryn
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Re : protein imbalance can predict pregnancy disorder

Postby caryn » Sun Oct 22, 2006 10:58 pm

If I am reading their study right, this test had an infinite odds ratio when administered in the correct weeks, which means that it did detect 100% of PE cases. That said, it's entirely possible that their sample didn't include anyone who developed a clot in the umbillical artery of an otherwise completely healthy and properly implanted placenta -- I bet there are ways to get PE that this test wouldn't pick up on, like that unexpected sudden clot, or things like car accidents that damage the placenta.

But yes, I'm pretty sure the intent here is to use this (it was a simple bloodwork test) as a diagnostic screening tool, to pull us out of the population of pregnant women before high bp and proteinuria appear, and give us more expectant management, in anticipation that we will develop the traditional symptoms of PE at some point.

Won't that be a *huge* public health advance??? Really I'm just amazed at how this whole research stream is panning out. Of course, it'll be a while while they develop this test, but I'm still so pleased to think that the next generation of women might know ahead of time, and be ready... I can't imagine but that it will save many lives.

jillmushet
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Re : protein imbalance can predict pregnancy disorder

Postby jillmushet » Sun Oct 22, 2006 04:08 pm

"A team of researchers from the National Institutes of Health have now identified high levels of two proteins in the maternal blood that could be predictive of preeclampsia..."

Are the researchers saying "could be predictive of pe" just to be cautious? Will this test predict 100% of pe cases? If yes, years down the road will we see a diagnosis of pe from this protein level test?...In other words, will this test set a new criteria for pe diagnosis, and replace the protein in urine/ high bp criteria of today?

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caryn
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protein imbalance can predict pregnancy disorder

Postby caryn » Sun Oct 22, 2006 05:12 am

"A team of researchers from the National Institutes of Health have now identified high levels of two proteins in the maternal blood that could be predictive of preeclampsia..."

http://www.wvec.com/news/health/stories ... f13dd.html

This study was presented at the recent NIH/NICHD workshop Eleni and I attended. [:)] Here's some links to older news articles about the same proteins:

http://www.preeclampsia.org/forum/viewtopic.php?t=18980
http://www.preeclampsia.org/forum/viewtopic.php?t=18614
http://www.preeclampsia.org/forum/viewtopic.php?t=18602
http://www.preeclampsia.org/forum/viewtopic.php?t=18110
http://www.preeclampsia.org/forum/viewtopic.php?t=17651

As you can see, this has been absolutely all over the place lately. I hope it continues to pan out and we get a screening test in the next five years or so (treatment, of course, is even further off -- but screening certainly has the potential to save a lot of lives.)

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