Any long term studies done about use of lda in pregnancy?

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riehlism
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Re: Any long term studies done about use of lda in pregnanc

Postby riehlism » Mon Jun 06, 2011 11:19 am

Also, I noticed that since I started taking it, it seems to bother my stomach a little. Is that normal? I hope it won't bother the stomach of the baby!
That's a common side effect. Try taking it with a meal. I believe it's worse when you don't eat something.

On another note, I feel you on being anxious about all these interventions. Aside from your medical team, have you considered talking to a counselor about dealing with the anxiety. Trying for a new baby is a big transition and the type of guidance you need may be different than loss/grief (if you saw a therapist for that reason like I did).

Maybe a counselor/therapist can help you organize your thoughts and concerns. Anxious might not help the baby making process easy. It might be better to start without a whole lot tension inside.
Jasmin: Severe PE/HELLP and delivered at 24+6 & PCOS (29) Hubby Bubby, Frank (29)
Baby Blue stopped in to say hello and goodbye on 6/3/10
Baby Lucas was born on 10/13/11, PE and HELLP-free! Thank you baby aspirin and Lovenox
http://www.ehd.org/pregnancy-calendar.php?id=18192

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jean
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Re: Any long term studies done about use of lda in pregnanc

Postby jean » Mon Jun 06, 2011 11:03 am

Very true. Thank you for sharing your thoughts. I am definitely trying to relax and just not think about it all right now. (And did watch a silly movie this weekend as well..hee hee :)
Our first son was born and passed in Feb of 2010. Born at 29 weeks due to HELLP and passed due to NEC. We miss him every day. :~(

Our second son was born at 39 weeks gestation in Nov of 2011. No HELLP or pre-e! Took LDA starting at week 12 and went off of it at week 38!

http://findingtherainbowconnection.blogspot.com/

jenndola
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Re: Any long term studies done about use of lda in pregnanc

Postby jenndola » Mon Jun 06, 2011 03:44 am

I haven't posted in a very long time, so forgive me if I'm a little rusty.

I lost 3 pregnancies before I finally had a live birth; in the second pregnancy I developed HELLP Syndrome at 19.5 weeks. After my 3 year child-bearing hiatus, I went back to see my perinatologist and we had a frank discussion about my difficulties. He suggested a highly experimental medication (the name of which I generally don't divulge on the forums) with the idea that we would "throw everything at the wall and see what stuck."

I thought about that for a while. I didn't really want to be a human guinea pig, but I knew what I'd done previously hadn't worked, so I took a deep breath, said a really big prayer, and went for it. I now have two live babies. There's no conclusive proof or controlled studies that show it's because of the medication, but that's okay, because - two live babies. What do I care how it happened?

Were my pregnancies scary? Oh, yes. And both of my sons were born early (31.5 and 29 weeks). And my mother, in her not-helpful way, will sometimes ask if I think they were premature because of the experimental medication (I don't), and I'll smile and say, "It doesn't really matter. They're alive and healthy."

I had a point to this post. Really, I did. And it wasn't "give yourself over to medicine! It's fun!" It was more along the lines of...your pregnancy is going to be scary. You're fixating on the LDA, and I kind of wonder if it's because the LDA is one of the few things you feel is within your control to change. (Whoa. I didn't intend to start psychoanalyzing you, either. I need to stop typing at 2:30 in the morning.)

And not to be horribly bleak or even say this is the trade-off, but I'd take a baby with a valve defect over no baby at all. That's my brutally honest 2:30 a.m. opinion on the matter.

You know what? You're already a fantastic mama. Look at you, worrying yourself to death. But this pregnancy isn't going to get any less stressful, so I highly recommend you do what Caryn suggested - take some deep breaths and watch some silly movies. There are a lot of women here to help you along the way, but sadly, we can't reach into your brain and wipe away your worries (which would be creepy anyway).

I'm going to stop typing now. Hang in there.
So I have this silly thing called Antiphospholipid Syndrome, which led to a blood clot in my brain, a miscarriage at 14 weeks,
HELLP Syndrome at 19.5 weeks, and a miscarriage at 6 weeks.

Pregnancies 4 & 5 produced two sons. Hooray!
Big G, born at 31.5 weeks in 2005
Little G, born at 29 weeks in 2008

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jean
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Re: Any long term studies done about use of lda in pregnanc

Postby jean » Thu Jun 02, 2011 08:10 am

Thanks-yes, silly movies are a good distraction. :) And thank you for the info. That reassurance means a lot to me.
Our first son was born and passed in Feb of 2010. Born at 29 weeks due to HELLP and passed due to NEC. We miss him every day. :~(

Our second son was born at 39 weeks gestation in Nov of 2011. No HELLP or pre-e! Took LDA starting at week 12 and went off of it at week 38!

http://findingtherainbowconnection.blogspot.com/

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caryn
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Re: Any long term studies done about use of lda in pregnanc

Postby caryn » Wed Jun 01, 2011 09:05 pm

Deep breaths. :) Compare the risks. Do you drive? 'Cause the odds of dying in a car wreck are way higher than the risks to you.

Your doc's right that the developmental window for formation of major organs is past, for what that's worth! And online information is often worthless; we're very lucky here to have a team of actual researchers - the people on the cutting edge of the science - willing to contribute. If there were really significant risks from LDA I am completely confident that our Experts would have nixed the idea of baby aspirin a loooooong time ago.

The hard thing is accepting that you really have no control. But you don't. Catherine swears by silly movies to keep you from thinking about this.
Science! The articles you don't want to miss:
The Preeclampsia Puzzle (New Yorker) and Silent Struggle: A New Theory of Pregnancy (New York Times)
Looking for recent articles and studies?
A chance to participate in research? For us on Facebook or Twitter?

Caryn, @carynjrogers, who is not a doctor and who talks about science stuff *way* too much
DS Oscar born by emergent C-section at 34 weeks for fetal indicators, due to severe PE
DD Bridget born by C-section after water broke at 39 weeks after a healthy pregnancy

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jean
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Re: Any long term studies done about use of lda in pregnanc

Postby jean » Wed Jun 01, 2011 06:58 pm

I'm just feeling so sick with worry. Now that I've started taking it, I don't imagine I can just stop. (Of course I'd talk to my dr. about it before doing anything like that) But I don't know that I would want to stop taking it either in case it would help. But I'm just reading all of these horrible things online about what it can do to your pregnancy....reroute the blood flow for the baby, the thing about prematurely closing the hole in the heart, making the intestines grow outside of the body, placental abruption, etc.... some of these things I don't know if they are results of taking lda or regular aspirin though. And what are the odds/stats of these things happening? I can't seem to find this info, even on pubmed. :(
I called my peri about a week ago with my concerns, but he was tired of hearing from me and of my worries (remember, he is the ONLY peri anywhere near me)...and he said that he thought the baby would be developed enough not to worry about major organs, and that long term studies said there were no major issues.
I just feel like crying. I don't know what to do. Why didn't he tell me about all of these potential risks and problems I'm reading about online. And now I've been taking it for over a week. But I don't want blood clots in my placenta either. :~(
I know nobody on here can really give me an answer of what to do, or anything to help. I just don't know what to do. I feel like a wreck. I appreciate having you all to talk to about it and to refer to for support and information. I guess the other problem I have is that my ob and peri did not see eye to eye on whether or not I should take the lda. I went with the peri-because I figured he's the "specialist" (and on top of that, it sounds like a lot of ppl on here are taking lda as well)....but it does not give me confidence to have the differing opinions from my doctors.
Last edited by jean on Thu Jun 02, 2011 08:10 am, edited 1 time in total.
Our first son was born and passed in Feb of 2010. Born at 29 weeks due to HELLP and passed due to NEC. We miss him every day. :~(

Our second son was born at 39 weeks gestation in Nov of 2011. No HELLP or pre-e! Took LDA starting at week 12 and went off of it at week 38!

http://findingtherainbowconnection.blogspot.com/

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caryn
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Re: Any long term studies done about use of lda in pregnanc

Postby caryn » Sun May 29, 2011 08:46 pm

I don't recall that effect showing up in the population of preeclamptics, when they tested baby aspirin on us. Maybe I'm misremembering, though. We're a unique population, so effects that show up in other populations (aka normal pregnant women) don't always show up on us, and vice versa.

(I do know is that the PDA often doesn't close as expected at delivery with preemies. My son's was open for about a month postpartum.)
Science! The articles you don't want to miss:
The Preeclampsia Puzzle (New Yorker) and Silent Struggle: A New Theory of Pregnancy (New York Times)
Looking for recent articles and studies?
A chance to participate in research? For us on Facebook or Twitter?

Caryn, @carynjrogers, who is not a doctor and who talks about science stuff *way* too much
DS Oscar born by emergent C-section at 34 weeks for fetal indicators, due to severe PE
DD Bridget born by C-section after water broke at 39 weeks after a healthy pregnancy

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cmccaffrey
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Re: Any long term studies done about use of lda in pregnanc

Postby cmccaffrey » Sat May 28, 2011 12:58 am

My doctor told me its normal to have some stomach agitation while on aspirin, but I don't know what kind of troubles your having, so you may want to check with your doctor.
Christa (25) & J (26)
Mommy to:
Mason born 10.11.10 @ 30+3 wks due to Severe Pre-E. Only lived 2.5 days
Noah born 2.1.12 @ 38 weeks thanks to lots of doctors visits, LDA, Lovenox and no preeclampsia!

learn more about our story... http://tinyurl.com/7a979vy

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jean
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Re: Any long term studies done about use of lda in pregnanc

Postby jean » Sat May 28, 2011 09:21 am

Also, I noticed that since I started taking it, it seems to bother my stomach a little. Is that normal? I hope it won't bother the stomach of the baby!
Our first son was born and passed in Feb of 2010. Born at 29 weeks due to HELLP and passed due to NEC. We miss him every day. :~(

Our second son was born at 39 weeks gestation in Nov of 2011. No HELLP or pre-e! Took LDA starting at week 12 and went off of it at week 38!

http://findingtherainbowconnection.blogspot.com/

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jean
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Re: Any long term studies done about use of lda in pregnanc

Postby jean » Wed May 25, 2011 10:59 pm

Does anyone know about the likelihood of having premature closure of the ductus arteriosus from taking lda? I did talk to my peri earlier this week, but he was in a hurry and just told me that there were no real birth defect risks when starting to take it at 12 weeks. I worry about this fetal heart stuff though too..
Our first son was born and passed in Feb of 2010. Born at 29 weeks due to HELLP and passed due to NEC. We miss him every day. :~(

Our second son was born at 39 weeks gestation in Nov of 2011. No HELLP or pre-e! Took LDA starting at week 12 and went off of it at week 38!

http://findingtherainbowconnection.blogspot.com/


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