What happens biologically during Pre-E

[debbiec]

Could there be a link between pre e and sub chorionic hemorrhage?

[caryn]

I'm going to bump this thread into active topics, because it's a *really* useful thread.

*waves to the lurkers*

[bsherricca]

I just got my post pe 6 week blood test results back and they all came back as normal (except for slight anemia) ie i have no underlying conditions ...the tests they did were B2 Glocoprotien i and cadiolin AB ...are there other tests that should have been done ? are there other instances where women have had no underlying contions but still developed PE? ...

[MomTimesThree]

Just wondering if there was any research on why some pre-e is so quick moving and some so slow? Have any protective factors been discovered or is it all just luck of the draw?

[MomTimesThree]

This thread has been so interesting. I wondered if anyone knew if the etiology of super-imposed pre-e was different. If I understand correctly in "regular" PE it all originates from placenta issues. When you have super-imposed pre-e is that still the case? Or is it that because you have PIH, reach those pesky 140/90s and then are spilling protein which makes you pre-e diagnosable you get the label even though biologically the same thing isn't happening.

I hope this makes a lil' bit of sense. Our pre-e with our 2nd lil' one was so abnormal, and all our early labs placenta labs were normal (as they are this time around). Especially because with this lil' we were already spilling protein at 10weeks if last time was really super-imposed, even though I didn't have any blood pressure issues with my first, but maybe we would have if we had gone to term. Our bp is already starting to rise a lil' bit, now firmly trending in the 130s, and at a 2nd 24hr at 18 or 19 weeks creeping to 242. (If it goes any higher we'll be put on bp meds) I wonder if things continue progressing if this time around we would get a super-imposed label. Though gosh... I hope all this thinking about this is all for nothing and we get a pregnancy without any diagnosis except for pregnant with big fat full term healthy baby.

[Sara35]

Thank you so much. I am pretty scared at the moment. Am 36+2 and have been watched non stop since 32 weeks as protein in urine with raised BP which slowly raised enough to 160/103 last week that they put me on labetolol...200mg twice a day which brought bp down to 120/77 average. Today went in and it was 139/90 so am having an extra dose of labetolol. Have been told to come back in for monitoring and then if all well, they will give me a sweep at 37+2 (a week today). I am just a little nervous because the last 4-5 weeks have been a haze as been checked so often and am constantly linking every pain and strain to PE, feel like a hypochondriac.

[caryn]

Joy, yes, lots! Try this link:
http://www.preeclampsia.org/forum/viewt ... 12&t=43563

[momof4as]

I was told that they are studying a link between the genetics with the Father that could be contibuting to pe in the mother... any news on this? I makes sense since I had two children without PE and both kids with my husband I've had PE with.

[smz1789]

So glad I found this post... I learned more about what pre-e really is in this single thread, then I've ever heard in a doctors office, or read in a pregnancy book!
Thank you for sharing this insight ladies!

[caryn]

I think IUGR is something they'll watch for simply because the correlation between PE and IUGR is known to be very strong, likely due to the shallow implantation. They're watching for horses, not zebras, and so they'll watch for IUGR.

But yeah, superimposed preeclamptics with bigger babies - ie a lot of us chronics - are probably pulling off some other set of problems that just look similar. Oscar was almost 5 pounds at 34 weeks, and in a normal pregnancy, would have doubled his weight between 34 weeks and delivery. So a 10-pound firstborn. I *really really suspect* that the maternal-fetal conflict issue in my case was simply that my body tried to modulate bloodflow downward from a normal (or perhaps deeper than normal) implantation and the placenta fought back, triggering the whole PE spiral. (My husband and I are both bossy sorts, by the way.)