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 Preeclampsia and risk of subsequent diabetes
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Caryn
Ask the Experienced Moderator

CarynFamily
USA
8780 Posts

Posted - 10/26/2009 :  7:16:28 PM  Show Profile  Reply with Quote
Preeclampsia was associated with a higher risk of diabetes adjusting for age, primigravidity, and gestational diabetes (hazard ratio, HR 1.82, 95%CI 1.26, 2.62) and in women without gestational diabetes (n = 30,109; HR 1.86, 95%CI 1.22, 2.84).

http://www.ncbi.nlm.nih.gov/pubmed/19843005

Great. Even if you didn't get GD, you're at almost double the risk of developing diabetes. In fact, there's hardly any difference between the two groups.

Information provided on this site is provided for informational purposes only and is not meant to substitute for the advice provided by your own physician or other medical professional. You should not use the information contained herein for diagnosing or treating a health problem or disorder, or prescribing any medication. The Preeclampsia Foundation presents all data as is, without any warranty of any kind, express or implied, and is not liable for its accuracy, for mistakes or omissions of any kind, nor for any loss or damage caused by a user's reliance on information obtained on the site. Professional opinions on this condition vary greatly. The Preeclampsia Foundation endorses no one course of treatment or "cure".

Sonja
ATE and Pregnant Again Moderator

joy124March07
5612 Posts

Posted - 10/26/2009 :  8:12:11 PM  Show Profile  Reply with Quote
I don't even know what to say!

Sonja Mom to:
Kira 3/02 37.5 weeks - sudden onset pre-e
Amelia 5/04 37.5 weeks - started meds at 16 weeks - diagnosed with "high cardiac output."

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missgamecock
Senior Member

kirstensara5
USA
6191 Posts

Posted - 10/26/2009 :  8:32:30 PM  Show Profile  Reply with Quote
That does NOT make me happy!!! Not having GD was the one thing that I passed in pregnancy!

Sabrina, mom of Kirsten Scout DOB 3/27/99, 5lbs, 1oz., 36 weeks, severe PE, & Sara Grace DOB 6/28/05, 6lbs 1oz., Severe PIH, 35 weeks 5 days. #3 Peyton, lost at 13 weeks 3 days on 2/21/08
4th - Lost at 5 weeks 4/30/08.
DD #3, Caitlyn Elyse (Catie), a Rainbow Baby, DOB 1/16/09, 5lbs 7 ozs, 36 weeks, Diagnosed w/ chronic HTN, RT Uterine Artery Notching, and mild PE before delivery, severe after.
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Blythe
Ask the Experienced Moderator

heather
USA
2277 Posts

Posted - 10/26/2009 :  8:41:11 PM  Show Profile  Reply with Quote
Did they control for BMI? Did they speculate on the correlation?

I'm just not pleased to hear this and want an alternative explanation! ;-b

Heather - mom to
DS #1 - 7/18/03, 37 weeks - Mild PE, 5lbs, 8oz, 4 days in NICU
DS #2 - 8/11/06, 36 1/2 weeks, 6lbs, 14oz!!! Induced for diagnostic BP. No NICU!
DD #3 - 9/10/09, high bp at 33 1/2 weeks, induced at 37 weeks, 5 pounds, 12 ounces - healthy girl!
"Thank God for the internet - otherwise my children would be raised in a med school library"
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brooklynsmom
Advanced Member

USA
625 Posts

Posted - 10/26/2009 :  9:30:30 PM  Show Profile  Reply with Quote
Well, since I had one in each pregnancy, I guess I am really in trouble, then, hey?

Nikki 30
DH-Dave 31
DD-Brooklyn 34 weeks 2 days, 3 lbs 10 oz
PE/HELLP Syndrome
DD-Chloe Anne 39 weeks 2 days, GD, but PE FREE-WOO HOO!
DD-Kinsley Elizabeth-another PE Free pregnancy!
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southerngirl108
Starting Member

southerngirl108
US
44 Posts

Posted - 10/26/2009 :  10:58:39 PM  Show Profile  Reply with Quote
Great.....

DD Madelyn Ann born 11/22/07 @ 35w6d (PE) 5 lb., 1 oz.(bedrest since 34w3d)
DS Noah David born 11/18/09 @ 37w4d (PIH and severe PE) 5lb., 6 oz.(bedrest since 32w3d)
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For Faith
Moderator Emeritus

Faith Kristine
USA
2533 Posts

Posted - 10/27/2009 :  7:05:33 PM  Show Profile  Reply with Quote
Wow, had never heard this before......have Type I and Type II in my family (but no GD for me).....guess I am destined for it.....

Jill - mommy to:
Tyler - 4/7/00 (36wks, 7lbs3oz, mild PE); Angel - 1/20/03 11wks;
Faith Kristine - 1/5/04-1/30/04 (30wks, 3lbs3oz, severe PE, NEC/Sepsis(preemie complications));
Dylan - 5/30/05 (39wks!, 8lbs14oz, PIH, but NO PE) our joy after sorrow
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angelr
Starting Member

US
18 Posts

Posted - 04/22/2010 :  10:06:22 PM  Show Profile  Reply with Quote
I had GD both pregnancies, PE both times. The first time (3 y ago) my blood glucoses went back to normal after delivery. This time, not so lucky. I have Type 2 DM now but still diet controlled (I am amazed how few carbs one should really be eating!) My BMI is 23, I am very active and have never been overweight. No one in my family has or had DM on either side. So I believe I am the perfect case of this phenomenon :o) Not happy about it but I can manage it.
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Rebeccac
Advanced Member

USA
784 Posts

Posted - 04/22/2010 :  11:22:32 PM  Show Profile  Reply with Quote
So on the flip side, diabetes makes you more prone to preeclampsia (I already had (have) it)?

Rebecca/DS born at 35 weeks due to pre-e and Class 1 HELLP
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angelr
Starting Member

US
18 Posts

Posted - 04/23/2010 :  09:08:34 AM  Show Profile  Reply with Quote
Yes, diabetes is one of the known risk factors for PE. Elevated blood glucose causes endothelial damage(lining of the blood vessels)which is why diabetics are prone to micro and macro-vascular damage. The maternal manifestation of preeclampsia is widespread endothelial derangement so I suppose anything that predisposes you to this damage can only work hand in hand to make things worse on both ends :o(
But on a positive note I know someone who is a very, very "brittle" diabetic who delivered a healthy baby at age 42 with nary a sign of PE...
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Caryn
Ask the Experienced Moderator

CarynFamily
USA
8780 Posts

Posted - 04/23/2010 :  4:03:08 PM  Show Profile  Reply with Quote
Yes, that's how I understand it too, although it seems to conflict kind of a lot with the idea that the damage from preeclampsia entirely reverses after delivery!

Science is getting us closer to finding a cause, and even a cure. The articles you don't want to miss:
The Preeclampsia Puzzle (New Yorker) and Silent Struggle: A New Theory of Pregnancy (New York Times)
Looking for recent articles and studies? Lectures from researchers? A chance to participate in research?

Caryn, who is not a doctor and who talks about science stuff *way* too much
DS Oscar born by emergent C-section at 34 weeks for fetal indicators, due to severe PE
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angelr
Starting Member

US
18 Posts

Posted - 04/23/2010 :  6:40:48 PM  Show Profile  Reply with Quote
I am not sure there is any way to know that everything resolves entirely at the cellular level...
It's a chicken and egg situation... did the preeclampsia do something to predispose us further or would we have just developed HD and DM anyway. With GD there is a hyperinsulinemia along with insulin resistance and we know that pancreatic beta cells can "burn out" eventually leading to Type 2 DM. So on that end I am not surprised that I have ended up here. Interestingly, everyone in my family has HD but no one has ever developed PE or diabetes on either side. So bad luck, coupled with bad genes, add preeclampsia and stir :o)
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Kara
Volunteer Development Director

Kara
USA
6501 Posts

Posted - 05/06/2010 :  10:59:28 PM  Show Profile  Visit Kara's Homepage  Send Kara a Yahoo! Message  Reply with Quote
Ugh. And I have a family history of Type 2 diabetes. Though no GD for me.

Kara, Volunteer Development Director - Kara.Boeldt@preeclampsia.org
Mom to Avery, 31 weeks, 2 lbs., 7.5oz IUGR, Severe PE, underlying disorders

*Want to raise Awareness but need Funding?
**Become an Official PF Volunteer Here

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AnneS
Assistant Forum Administrator

parkerandmom
USA
2536 Posts

Posted - 05/07/2010 :  12:14:56 PM  Show Profile  Reply with Quote
BAH!

Anne
DH Richard
DS Parker 7/6/03(severe pe)33wks
DS Griffin 2/17/06-2/21/06, 25 wks,IUGR and Low Amniotic Fluid
DD Clover 6/25/08 35 wks, NO PE!
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